We were able to identify >1100 individual patient uses based on published literature of IBA use (primarily for VVC).3,710,12,1629,31s53s Most described 600 mg once daily or BID for 7 to 14 days,12,16,2027,29,31s,36s,37s,39s,41s,44s51s whereas others described BID for 1 to 2 months,710,43s,53s or extended or suppressive regimens.3,17,22,23,25,26,29,35s,40s Perhaps the greatest evidence for the safety of IBA is that despite this literature, we were not able to find published reports since the 1880s of serious toxicities. boric acid So it doesn't hurt fertility in any way other than it can very well kill off sperm. We did not find any literature regarding effects on fertility of IBA use. In the animal literature, Weir et al.66s established an LD50 (the amount of material causing death of 50% of test animals) of 3450 mg BA/kg (603 mg B/kg) administered as an oral dose for male Sprague-Dawley rats, and 4080 mg BA/kg (713 mg B/kg; i.e., 285,600 mg BA in a 70-kg human) for females. One observational study determined that boron intake did not correlate with bone mineral density in humans. Accessed July 15, 2022. If you are a Mayo Clinic patient, this could Vaginitis due to. The Boron Content Of Borax Is 11. There were 5 minor malformations observed versus 4.6 expected (SRR, 1.10 [95% CI, 0.362.53]). Global burden of recurrent vulvovaginal candidiasis: A systematic review. In a case-control study comparing healthy people to people with lung cancer, researchers found that those with the lowest boron intake had almost twice the risk of lung cancer. Charlton BM, et al. This label will contain important information, including the number of active ingredients per serving and other added ingredients (like fillers, binders, and flavorings). Cathy Wong is a nutritionist and wellness expert. If we combine this information with your protected Much of acute human toxicity data relates to case series of reported accidental or purposeful oral ingestion, often in children,56s58s,61s of BA-containing insecticides or cleaning products.57s,59s,61s Orally ingested BA seems to be nearly 100% systemically absorbed,63s,64s although quickly renally excreted. Immune system disorders. Integr Med (Encinitas). High doses of oral BA given daily in pregnancy clearly have teratogenic effects in animal models; data on other obstetric outcomes are scarce. You should never ingest boric acid. The concern is that boron may increase production of hormones such as estrogen and testosterone in certain individuals. Table 4, https://links.lww.com/OLQ/A753). The National Institutes of Health (NIH) cautions that boron supplements or high dietary intake of boron may be harmful to people with hormone-sensitive conditions, including breast cancer, endometriosis, and uterine fibroids. Mayo Clinic does not endorse companies or products. It may be reasonable to discuss the sparsity of data on pregnancy and the drug threshold of embryopathy in IBA to facilitate a joint informed-consent process to consider pregnancy avoidance while in use or defer if pregnancy is planned. For example, a search on a large Internet retailer reveals >20 brands of boric acid (BA)containing vaginal suppositories, marketed for indications ranging from vaginal odor, discharge, and dryness to VVC, BV, and dyspareunia or correcting vaginal pH. Tell your doctor if you are pregnant or plan to become pregnant. However, we feel IBA should be prescribed by a provider; given uncertainties, we cannot recommend unregulated use of OTC products. The lowest observed adverse effect levelthat is, the lowest dose at which an observed adverse effect level was demonstrated on the fetuseswas 76 mg BA kg1 d1 or 13 mg B kg1 d1. Vulvovaginal trichosporonosis. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. use Use this medicine only with the applicator provided. The Importance of Boron Nutrition for Brain and Psychological Function. Vaginal boric acid may also be used for purposes not listed in this medication guide. Boron is a naturally occurring element found in plant foods.
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